Difference between DNA Replication in E.coli and Mammalian cells

Difference between DNA Replication in E.coli

and Mammalian cells

DNA replication in E.coli

    1. DNA polymerase III is involved in leading strand synthesis.    

    2. synthesis is initiated by  primase.
    3. Extention of RNA primer into okazaki fragments is carried by DNA polymerase II

4. Primer removal and filling of gaps between Okazaki fragments is carried out by

DNA polymerase I.

 

 DNA replicationMammalian cell

1. DNA polymerase delta is involved in leading strand synthesis. 
2. Lagging strand synthesis is initiated by complex of primase and DNA polymerase alpha.

3. Extension of RNA primer into Okazaki fragments is carried out by DNA polymerase delta.
4. Primer removal and filling of gaps between okazaki fragments is out by DNA polymerase delta.